A biomarker is not an outcome.
“Raises NAD+” or “improves an aging clock” is not “you live longer or healthier.” We say which one the evidence actually shows.
The method
How we check.
The verdict comes first, the evidence sits under it, and the limits get named out loud. Confident about the method; humble about what it can’t tell you.
The Caveat Standard
Five steps, every time.
- 01 · Source
Trace the claim to its primary source. No source, no verdict.
- 02 · Quote
Quote it exactly, what was said, not the paraphrase.
- 03 · Grade
Grade the evidence GRADE-style: A high → D very low.
- 04 · Conflicts
Follow the funding, who paid for the study, and the claimant.
- 05 · Caveat
Name the limit, and whether it's untested or disproven.
The verdict
Five verdicts. One stays apart.
Unsupported
No credible evidence supports the claim as stated.
Misleading
A kernel of truth, framed to imply far more than the evidence shows.
Mixed
Partly supported, partly not, it depends on the specifics.
Supported
The claim matches solid human evidence.
Unproven
Not shown, but not disproven. Plausible, and untested in humans. An honest grade, not a failing one.
Evidence grade
GRADE-style certainty.
A
High certainty
B
Moderate certainty
C
Low certainty
D
Very low certainty
The verdict says whether the claim matches the evidence. The grade says how far the evidence itself can be trusted, downgraded for small samples, short trials, surrogate endpoints, weak design, inconsistency, and funding conflicts.
Principles
Five we repeat.
Mechanism is not proof.
A clean story about why something should work is the beginning of a question, not the answer. Plausible is labelled plausible.
Follow the funding.
Industry-sponsored research favours the sponsor. We report who paid for each study and weight independent replication higher.
Absence of evidence ≠ evidence of absence.
Unproven is not disproven. We're as skeptical of confident dismissal as of confident hype, and we explain why a trial may never exist.
Never fabricate a citation.
Every source is opened and verified; quotes are exact. For a claim-checker, a single invented reference would be fatal, so when in doubt, we cut it.
Independence is the product. No industry money, ever.
We’re funded by readers and by licensing the database to clinics and employers, never by the companies whose products we check. If that ever changes, this page changes first, in public.